Autophagy is involved in clearance of redundant or dysfunctional components. To maintain physiological functions properly and promoting survival, autophagy acts as a molecular mechanism. Dysfunction in autophagy causes many diseases such as neuro-degeneration, cancer and diabetes mellitus (DMJ, infectious diseases and aging. Inadequate or ineffective insulin or both are the main causes of diabetes mellitus. In T2DM, autophagy provides nutrients to uphold cellular energy at fasting and also removes injured organelles, lipids and miss-folded proteins. In addition, autophagy plays a key role to prevent dysfunction of pancreatic beta cell and insulin resistance. In this review, we stated the functions of autophagy in diabetes mellitus.
Keywords: Autophagy; Type2 diabetes mellitus; Pancreatic !3-cells; Insulin resistance.
31-Aug-2024
