The aim of this study was to determine the anthelmintic activity of ethanolic extract of F. racemosa against bovine parasite. After that, the isolated compounds were put through molecular docking and an ADME/T evaluation. The current investigation includes the use of ethanol extraction on dried leaves. The anthelmintic activity of the compound was determined with the help of an experimental model utilizing the worm Paramphistomum cervi, Schrödinger-Maestro v10.1 docking fitness was then used to conduct a molecular docking analysis to discover compounds with the highest activity against the Tubulin-Colchicine enzyme. Moreover, the Swiss ADME online-based application was used to review the ADME/T profiles. Preliminary phytochemical screening of ELFR revealed that it contains alkaloids, glycoside, flavonoids, tannins, gums, carbohydrate and quinone. ELFR showed a dose-dependent and statistically significant anthelmintic activity on experimental worm (Paramphistomum cervi).
Keywords: F. racemosa, Anthelmintic, Molecular docking analysis, ADME/T property
30-Jun-2023
