The goal of this research was to find out the phytochemical constituents as well as the antioxidant and thrombolytic potential of Axonopus compressus, a traditional medicinal herb. Qualitative analysis was used to screen the phytochemical content of the plant's ethanolic extract. The total phenolic content was measured using Folin-reagent Ciocalteu's reagent and total flavonoid content was determined using the AlCl3 colorimetric method to measure antioxidant activity. A clot lysis experiment was used to test the extract's thrombolytic effects. In phytochemical screening, carbohydrates, saponin, tannin, terpenoid, alkaloids, and flavonoids were found. The extract contained total phenolic compounds as 25.74 mg Gallic acid equivalent (GAE)/g of dried extract & total flavonoid compounds as 21.3 mg Quercetin equivalent (QE)/g dried extract. The extract exerted 2.74%, 13% & 15.26% lysis of the blood clot at a concentration of 1 mg/ml, 2 mg/ml and 3 mg/ml respectively in the thrombolytic activity test while 65% lysis was obtained for positive control (streptokinase) at (100000 I.U/ml) and 3.03% for negative control. Axonopus compressus possesses some phytochemicals, significant antioxidant activity and showed a dose-dependent increase in clot lysis in an in-vitro thrombolytic assay that could be promising to study its potential with high-performance research work.
Keywords: Axonopus compressus, Antioxidant, Thrombolytic, Streptokinase
Jul 03 2022 , 07:06 AM
nice
Sep 28 2024 , 10:20 AM
Hello kyau.edu.bd webmaster, Thanks for the comprehensive post!
28-Feb-2025
