Metformin hydrochloride is a diabetic medicine that contains 500 mg of metformin. It is biguanide, which is a kind of oral hypoglycemic agent. It is the first-line treatment for type 2 diabetes, especially in overweight or obese individuals. In Bangladesh, many metformin hydrochloride tablets are available through the global drug delivery system. Because numerous brands of metformin tablets are available in the Bangladesh pharmaceutical market nowadays, health practitioners are faced with a generic replacement dilemma. The study's objective was to assess the physicochemical equivalence of five brands of metformin hydrochloride tablets marketed in Bangladesh using in vitro tests. Official and non-official criteria such as weight uniformity, friability, hardness, disintegration, assay, and dissolving rate were used to establish the physicochemical equivalence of different brands of Metformin hydrochloride tablet brands. All the brands adhered to the approved standards.
Keywords: Metformin, Weight Variation, Friability, Disintegration, Hardness.
28-Feb-2025
